IU Researchers New Tool Invention Reveals Activity in Real-Time : Folder Name: News & Events: Department of Molecular and Cellular Biochemistry: Indiana University Bloomington

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IU Researchers New Tool Invention Reveals Activity in Real-Time

IU Researchers New Tool Invention Reveals Activity in Real-Time

Thursday, March 7, 2019

Michael VanNieuwenhze, a Standiford H. Cox Professor of Chemistry at IU Bloomington, is among the Indiana University researchers that collaborated on the study and invention of a new tool that highlights real-time tracking of structured activity from bacterial cell walls.

News at IU Bloomington released an article that explores how this new tool invention can advance research for new antibiotics.

From the study the article explores the design of 'new class of probes', called rotor-fluorogenic D-amino acids, or RfDAAs, which a patent has been filed by Indiana University on this technology.

"This new technology takes advantages of specific cellular enzymes to stick colored dyes -- or 'probes' -- into the walls of bacterial cells" - Dr. Michael VanNieuwenhze

Process of probes illuminating cell walls faster and clearer

Fig. 3: RfDAAs allow real-time imaging of PG synthesis in S. venezuelae. (Fig. 3 image courtesy of the study Fluorogenic D-amino acids enable real-time monitoring of peptidoglycan biosynthesis and high-throughput transpeptidation assays)

VanNieuwenhze, continues, "A video provides much more information about how cell walls grow, change and interact with their environment.

To read the entire article "Indiana University research advances search for new antibiotics", visit the News at IU Bloomington article:

Read the story at News at IU Bloomington

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Michael VanNieuwenhze