Department of Molecular and Cellular Biochemistry

David Giedroc earned a B.S. in Biochemistry from the Pennsylvania State University and Ph.D. in Biochemistry from the Vanderbilt University School of Medicine in 1984. Following a postdoctoral stint as an NIH postdoctoral fellow in the laboratory of the late Joseph Coleman at Yale University, he joined the faculty in the Department of Biochemistry and Biophysics at Texas A&M University in 1988. He was appointed Professor of Chemistry at Indiana University in 2007, and served as Chair of Department from 2010-2015. Prof. Giedroc is a Fellow of the AAAS and of the Royal Society of Chemistry.

Prof. Giedroc's research interests fall under a common umbrella he terms the biophysical chemistry of infectious disease. Work is ongoing in three separate projects: 1) transition metal homeostasis (metallostasis) in bacterial pathogens; 2) hydrogen sulfide (H2S) sensing and reactive sulfur species (RSS) in the major nosocomial pathogen, Staphylococcus aureus (MRSA); and 3) the replication of vertebrate coronaviruses, including the causative agent of Middle East Respiratory Syndrome (MERS). Prof. Giedroc seeks a molecular-level understanding of macromolecular structure, dynamics and regulation, and uses the tools of biophysical chemistry, bioinorganic chemistry, proteomic profiling and NMR structure determination.

Prof. Giedroc is Director of our Graduate Training Program in Quantitative and Chemical Biology.