Genome biochemistry is the study of the maintenance, expression and duplication of the genome and epigenome. Deficiencies in these processes have fundamental impacts on the health and viability of organisms, for example leading to cancer-predisposition phenotypes in humans.
Our faculty exploit a range of model organisms to address the mechanisms of DNA replication, DNA repair and gene transcription, as well as investigating the basis of chromosome compaction, organization and segregation. Our diversity of topics is mirrored in the range of techniques that we exploit. The world-leading facilities at IU allow a full complement of genetic, cell biological, biochemical, biophysical and structural approaches to be applied to elucidate the molecular basis of the propagation of life.