Department of Molecular and Cellular Biochemistry

Choi Lab

Our laboratory investigates the structure and mechanism of positive-strand RNA virus replication and infection machinery using multiple approaches combining X-ray crystallography, cryo-electron microscopy, and biochemical methods.  We are interested in how viral RNA genome structure influences viral replication processes and how viral replication enzymes coordinate negative- and positive-strand RNA synthesis.  These processes are key steps in viral replication that can be targeted for antiviral development.